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KMID : 0882420090770000188
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Korean Journal of Medicine
2009 Volume.77 No. 0 p.188 ~ p.191
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Sunitinib-induced reversible posterior leukoencephalopathy syndrome after rifampin discontinuation
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Kim Mi-Jung
Kim Hee-Jun
Bae Hyun-Mi
Sim Sung-Hoon
Lee Jeong-Ok
Cha Yong-Jun
Lee Se-Hoon
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Abstract
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Sunitinib is an oral tyrosine kinase inhibitor with anti-angiogenic activity that is used for the treatment of advanced renal cell carcinoma and advanced gastrointestinal stromal tumors after failure on imatinib. The most common adverse effects of sunitinib are fatigue, diarrhea, nausea, stomatitis, hypertension, hand-foot syndrome, and cytopenia. Sunitinib was recently reported to be associated with reversible posterior leukoencephalopathy syndrome (RPLS). Here, we report the case of a 76-year-old woman with sunitinib-induced RPLS that developed after rifampin discontinuation.
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KEYWORD
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Sunitinib, Posterior leukoencephalopathy syndrome, Carcinoma, Renal cell
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